| Knorr pyrrole synthesis | |
|---|---|
| Named after | Ludwig Knorr |
| Reaction type | Ring forming reaction |
| Identifiers | |
| RSC ontology ID | RXNO:0000497 |
The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3).[1][2][3] The method involves the reaction of an α-amino-ketone (1) and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2).[4]
- ^ Knorr, Ludwig (1884). "Synthese von Pyrrolderivaten" [Synthesis of pyrrole derivatives]. Berichte der deutschen chemischen Gesellschaft (in German). 17 (2): 1635–1642. doi:10.1002/cber.18840170220.
- ^ Knorr, Ludwig (1886). "Synthetische Versuche mit dem Acetessigester" [Synthetic experiments with the ester of acetoacetic acid]. Annalen der Chemie (in German). 236 (3): 290–332. doi:10.1002/jlac.18862360303.
- ^ Knorr, L.; Lange, H. (1902). "Ueber die Bildung von Pyrrolderivaten aus Isonitrosoketonen" [On the formation of pyrrole derivatives from isonitrosoketones]. Berichte der deutschen chemischen Gesellschaft (in German). 35 (3): 2998–3008. doi:10.1002/cber.19020350392.
- ^ Corwin, Alsoph Henry (1950). "The Chemistry of Pyrrole and its Derivatives". In Elderfield, Robert Cooley (ed.). Heterocyclic Compounds. Vol. 1. New York: Wiley. pp. 287 ff.