Komagataella

Komagataella
Komagataella phaffii[1] GS115
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Phaffomycetaceae
Genus: Komagataella
Y. Yamada, M. Matsuda, K. Maeda & Mikata, 1995
Species

See text

Komagataella is a methylotrophic yeast within the order Saccharomycetales. It was found in the 1960s as Pichia pastoris, with its feature of using methanol as a source of carbon and energy.[2] In 1995, P. pastoris was reassigned into the sole representative of genus Komagataella, becoming Komagataella phaffii.[3] Later studies have further distinguished new species in this genus, resulting in a total of 7 recognized species.[4] It is not uncommon to see the old name still in use in the context of protein production, as of 2023;[5] in less formal use, the yeast may confusingly be referred to as pichia.

After years of study, Komagataella is widely used in biochemical research and biotech industries. With strong potential for being an expression system for protein production, as well as being a model organism for genetic study, Komagataella phaffii has become important for biological research and biotech applications.[1][5]

  1. ^ a b De Schutter, K., Lin, Y., Tiels, P. (2009). "Genome sequence of the recombinant protein production host Pichia pastoris". Nature Biotechnology. 27 (6): 561–566. doi:10.1038/nbt.1544. PMID 19465926.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Koichi Ogata, Hideo Nishikawa & Masahiro Ohsugi (1969). "A Yeast Capable of Utilizing Methanol". Agricultural and Biological Chemistry. 33 (10): 1519–1520. doi:10.1080/00021369.1969.10859497.
  3. ^ Yamada, Yuzo; Matsuda, Minako; Maeda, Kojiro; Mikata, Kozaburo (January 1995). "The Phylogenetic Relationships of Methanol-assimilating Yeasts Based on the Partial Sequences of 18S and 26S Ribosomal RNAs: The Proposal of Komagataella Gen. Nov. (Saccharomycetaceae)". Bioscience, Biotechnology, and Biochemistry. 59 (3): 439–444. doi:10.1271/bbb.59.439. PMID 7766181.
  4. ^ Cite error: The named reference gbif was invoked but never defined (see the help page).
  5. ^ a b Heistinger, Lina; Gasser, Brigitte; Mattanovich, Diethard (2020-07-01). "Microbe Profile: Komagataella phaffii: a methanol devouring biotech yeast formerly known as Pichia pastoris". Microbiology. 166 (7): 614–616. doi:10.1099/mic.0.000958. ISSN 1350-0872. PMID 32720891.