Kv1.1

KCNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AFL
Identifiers
Aliases	KCNA1, AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1, potassium voltage-gated channel subfamily A member 1
External IDs	OMIM: 176260; MGI: 96654; HomoloGene: 183; GeneCards: KCNA1; OMA:KCNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,918,256 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	126,623,347 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; cerebellar hemisphere; ; primary visual cortex; ; right hemisphere of cerebellum; ; lateral nuclear group of thalamus; ; postcentral gyrus; ; putamen; ; caudate nucleus;
	Top expressed in
	sciatic nerve; ; pontine nuclei; ; deep cerebellar nuclei; ; lateral geniculate nucleus; ; medulla oblongata; ; medial vestibular nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; olfactory tubercle; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity; potassium ion transmembrane transporter activity; ion channel activity; protein binding; voltage-gated potassium channel activity; disordered domain specific binding; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	axon terminus; juxtaparanode region of axon; integral component of membrane; cytosol; perikaryon; cell projection; membrane; plasma membrane; synapse; integral component of plasma membrane; cell surface; cell junction; soma; dendrite; axon; potassium channel complex; apical plasma membrane; endoplasmic reticulum; paranode region of axon; presynaptic membrane; cytoplasmic vesicle; voltage-gated potassium channel complex; calyx of Held; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	regulation of muscle contraction; detection of mechanical stimulus involved in sensory perception of pain; cellular response to magnesium ion; startle response; regulation of membrane potential; cell communication by electrical coupling; neuronal signal transduction; regulation of ion transmembrane transport; ion transport; magnesium ion homeostasis; potassium ion transport; brain development; neuromuscular process; transmembrane transport; potassium ion transmembrane transport; neuroblast proliferation; detection of mechanical stimulus involved in sensory perception of touch; protein homooligomerization; hippocampus development; neuronal action potential; chemical synaptic transmission; positive regulation of voltage-gated potassium channel activity; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3736
	16485
	ENSG00000111262
	ENSMUSG00000047976
	Q09470
	P16388
	NM_000217
	NM_010595
	NP_000208
	NP_034725
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily A member 1 also known as K_v1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the KCNA1 gene.^[5]^[6]^[7] Isaacs syndrome is a result of an autoimmune reaction against the K_v1.1 ion channel.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111262 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047976 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Curran ME, Landes GM, Keating MT (1992). "Molecular cloning, characterization, and genomic localization of a human potassium channel gene". Genomics. 12 (4): 729–37. doi:10.1016/0888-7543(92)90302-9. PMID 1349297.
^ Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels. 3 (3): 213–20. PMID 8821794.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ Newsom-Davis J (1997). "Autoimmune neuromyotonia (Isaacs' syndrome): an antibody-mediated potassium channelopathy". Ann. N. Y. Acad. Sci. 835 (1): 111–9. Bibcode:1997NYASA.835..111N. doi:10.1111/j.1749-6632.1997.tb48622.x. PMID 9616766. S2CID 13231594.^{[permanent dead link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111262 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047976 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1349297-5] Curran ME, Landes GM, Keating MT (1992). "Molecular cloning, characterization, and genomic localization of a human potassium channel gene". Genomics. 12 (4): 729–37. doi:10.1016/0888-7543(92)90302-9. PMID 1349297.

[pmid8821794-6] Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels. 3 (3): 213–20. PMID 8821794.

[pmid16382104-7] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[pmid9616766-8] Newsom-Davis J (1997). "Autoimmune neuromyotonia (Isaacs' syndrome): an antibody-mediated potassium channelopathy". Ann. N. Y. Acad. Sci. 835 (1): 111–9. Bibcode:1997NYASA.835..111N. doi:10.1111/j.1749-6632.1997.tb48622.x. PMID 9616766. S2CID 13231594.^{[permanent dead link]}

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