LACTB

LACTB
Identifiers
Aliases	LACTB, G24, MRPL56, lactamase beta
External IDs	OMIM: 608440; MGI: 1933395; HomoloGene: 12755; GeneCards: LACTB; OMA:LACTB - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	63,142,061 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,882,766 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; monocyte; ; deltoid muscle; ; pancreatic epithelial cell; ; vastus lateralis muscle; ; tibialis anterior muscle; ; sperm; ; amniotic fluid; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	left lobe of liver; ; proximal tubule; ; interventricular septum; ; right kidney; ; primitive streak; ; human kidney; ; otic vesicle; ; seminal vesicula; ; ciliary body; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; peptidase activity; identical protein binding;
Cellular component	mitochondrion; cytosol;
Biological process	regulation of lipid metabolic process; proteolysis; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	114294
	80907
	ENSG00000103642
	ENSMUSG00000032370
	P83111
	Q9EP89
	NM_001288585; NM_032857; NM_171846
	NM_030717
	NP_001275514; NP_116246; NP_741982
	NP_109642
	Wikidata
View/Edit Human	View/Edit Mouse

Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene.^[5]^[6] This gene encodes a 54 kDa protein sharing significant sequence similarity to serine proteases of the penicillin binding protein and beta-lactamase superfamily occurring in bacteria. ^[7] It is involved in the regulation of the metabolic circuitry. A causal association has been found between LACTB and obesity.^[8] In breast cancer, LACTB has a tumor suppressor function by modulating lipid metabolism.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103642 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032370 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith TS, Southan C, Ellington K, Campbell D, Tew DG, Debouck C (November 2001). "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain". Genomics. 78 (1–2): 12–4. doi:10.1006/geno.2001.6643. PMID 11707067.
^ "Entrez Gene: LACTB lactamase, beta".
^ Peitsaro N, Polianskyte Z, Tuimala J, Pörn-Ares I, Liobikas J, Speer O, Lindholm D, Thompson J, Eriksson O (2008). "Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy". BMC Evolutionary Biology. 8 (1): 26. Bibcode:2008BMCEE...8...26P. doi:10.1186/1471-2148-8-26. PMC 2266909. PMID 18226203.
^ Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE (March 2008). "Variations in DNA elucidate molecular networks that cause disease". Nature. 452 (7186): 429–35. Bibcode:2008Natur.452..429C. doi:10.1038/nature06757. PMC 2841398. PMID 18344982.
^ Eriksson, Ove; Lalowski, Maciej; Lindholm, Dan (2017). "Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state". Frontiers in Physiology. 8: 396. doi:10.3389/fphys.2017.00396. ISSN 1664-042X. PMC 5462942. PMID 28642719.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103642 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032370 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11707067-5] Smith TS, Southan C, Ellington K, Campbell D, Tew DG, Debouck C (November 2001). "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain". Genomics. 78 (1–2): 12–4. doi:10.1006/geno.2001.6643. PMID 11707067.

[entrez-6] "Entrez Gene: LACTB lactamase, beta".

[pmid18226203-7] Peitsaro N, Polianskyte Z, Tuimala J, Pörn-Ares I, Liobikas J, Speer O, Lindholm D, Thompson J, Eriksson O (2008). "Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy". BMC Evolutionary Biology. 8 (1): 26. Bibcode:2008BMCEE...8...26P. doi:10.1186/1471-2148-8-26. PMC 2266909. PMID 18226203.

[pmid18344982-8] Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE (March 2008). "Variations in DNA elucidate molecular networks that cause disease". Nature. 452 (7186): 429–35. Bibcode:2008Natur.452..429C. doi:10.1038/nature06757. PMC 2841398. PMID 18344982.

[9] Eriksson, Ove; Lalowski, Maciej; Lindholm, Dan (2017). "Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state". Frontiers in Physiology. 8: 396. doi:10.3389/fphys.2017.00396. ISSN 1664-042X. PMC 5462942. PMID 28642719.

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