Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).
Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins.[5] The LAMP-1 glycoprotein is a type I transmembrane protein[6] which is expressed at high or medium levels in at least 76 different normal tissue cell types.[7] It resides primarily across lysosomal membranes,[8] and functions to provide selectins with carbohydrate ligands.[5] CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells,[9] and may also play a role in tumor cell differentiation and metastasis.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185896 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031447 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "LAMP1 lysosomal-associated membrane protein 1". Entrez Gene.
- ^ Eskelinen EL (2006). "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy". Molecular Aspects of Medicine. 27 (5–6): 495–502. doi:10.1016/j.mam.2006.08.005. PMID 16973206.
- ^ "LAMP1". The Human Protein Atlas.
- ^ Carlsson SR, Fukuda M (December 1989). "Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement". The Journal of Biological Chemistry. 264 (34): 20526–20531. doi:10.1016/S0021-9258(19)47094-4. PMID 2584229.
- ^ "LAMP1 - lysosomal-associated membrane protein1". Wikigenes.