LEFTY2

LEFTY2
Identifiers
Aliases	LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs	OMIM: 601877; MGI: 2443573; HomoloGene: 2434; GeneCards: LEFTY2; OMA:LEFTY2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,941,383 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,726,668 bp
RNA expression pattern
	Top expressed in
	decidua; ; body of uterus; ; Epithelium of choroid plexus; ; myometrium; ; sperm; ; left ovary; ; canal of the cervix; ; Descending thoracic aorta; ; testicle; ; ascending aorta;
	Top expressed in
	mesoderm; ; lateral plate mesoderm; ; embryo; ; epiblast; ; Gonadal ridge; ; embryo; ; neural plate; ; primitive streak; ; inner cell mass; ; paraxial mesoderm;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular matrix; extracellular region; platelet alpha granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	multicellular organism development; regulation of apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; cell growth; platelet degranulation; regulation of MAPK cascade; transforming growth factor beta receptor signaling pathway; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7044
	320202
	ENSG00000143768
	ENSMUSG00000066652
	O00292
	P57785
	NM_001172425; NM_003240
	NM_177099
	NP_001165896; NP_003231
	NP_796073
	Wikidata
View/Edit Human	View/Edit Mouse

Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene. ^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143768 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143768 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066652 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.

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