LGR5

LGR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BSR, 4BSS, 4BST, 4BSU, 4KNG, 4UFR, 4UFS
Identifiers
Aliases	LGR5, FEX, GPR49, GPR67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine rich repeat containing G protein-coupled receptor 5
External IDs	OMIM: 606667; MGI: 1341817; HomoloGene: 20807; GeneCards: LGR5; OMA:LGR5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	71,586,310 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	115,423,685 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; gastrocnemius muscle; ; placenta; ; thoracic diaphragm; ; skin of hip; ; spinal ganglia; ; vastus lateralis muscle; ; biceps brachii; ; muscle of thigh; ; right uterine tube;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; lip; ; olfactory bulb; ; paramesonephric duct; ; neural layer of retina; ; lumbar subsegment of spinal cord; ; calvaria; ; anterior horn of spinal cord; ; adrenal gland; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; protein-hormone receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; integral component of plasma membrane; trans-Golgi network membrane; membrane;
Biological process	positive regulation of canonical Wnt signaling pathway; hair follicle development; inner ear development; G protein-coupled receptor signaling pathway; epithelial cell proliferation involved in renal tubule morphogenesis; regulation of cell population proliferation; oocyte differentiation; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; hormone-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8549
	14160
	ENSG00000139292
	ENSMUSG00000020140
	O75473
	Q9Z1P4
	NM_001277226; NM_001277227; NM_003667
	NM_010195
	NP_001264155; NP_001264156; NP_003658
	NP_034325
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene.^[5]^[6] It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139292 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020140 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McDonald T, Wang R, Bailey W, Xie G, Chen F, Caskey CT, Liu Q (Jul 1998). "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem Biophys Res Commun. 247 (2): 266–70. doi:10.1006/bbrc.1998.8774. PMID 9642114.
^ McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, Kirschmeier P, Samatar AA (April 2006). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. doi:10.4161/cbt.5.4.2521. PMID 16575208.
^ Hsu SY, Liang SG, Hsueh AJ (December 1998). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/mend.12.12.0211. PMID 9849958.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139292 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020140 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9642114-5] McDonald T, Wang R, Bailey W, Xie G, Chen F, Caskey CT, Liu Q (Jul 1998). "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem Biophys Res Commun. 247 (2): 266–70. doi:10.1006/bbrc.1998.8774. PMID 9642114.

[McClanahan_2006-6] McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, Kirschmeier P, Samatar AA (April 2006). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. doi:10.4161/cbt.5.4.2521. PMID 16575208.

[Hsu_1998-7] Hsu SY, Liang SG, Hsueh AJ (December 1998). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/mend.12.12.0211. PMID 9849958.

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