Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene .[ 5] [ 6] G-protein coupled receptors LGR4 and LGR5 , LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo. [ 7]
This gene encodes a member of the leucine-rich repeat -containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants .[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000133067 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042793 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7" . Mol Endocrinol . 14 (8): 1257–71. doi :10.1210/me.14.8.1257 PMID 10935549 . ^ a b "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6" .^ Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma" . Nature Genetics . 49 (11): 1624–1632. doi :10.1038/ng.3957 . PMC 5662105 PMID 28945253 . 
