LILRB1

LILRB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0
Identifiers
Aliases	LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
External IDs	OMIM: 604811; HomoloGene: 88463; GeneCards: LILRB1; OMA:LILRB1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,638,022 bp
RNA expression pattern
	Top expressed in
	spleen; ; monocyte; ; appendix; ; granulocyte; ; blood; ; lymph node; ; bone marrow cells; ; upper lobe of left lung; ; right lung; ; C1 segment;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; MHC class I receptor activity; SH2 domain binding; protein phosphatase 1 binding; HLA-A specific inhibitory MHC class I receptor activity; HLA-B specific inhibitory MHC class I receptor activity; MHC class I protein binding; amyloid-beta binding; protein binding; MHC class Ib receptor activity; MHC class Ib protein complex binding; MHC class Ib protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; extracellular region; external side of plasma membrane;
Biological process	negative regulation of endocytosis; dendritic cell differentiation; negative regulation of mononuclear cell proliferation; negative regulation of interferon-gamma production; adaptive immune response; Fc receptor mediated inhibitory signaling pathway; negative regulation of osteoclast development; immune system process; response to virus; receptor internalization; negative regulation of cell cycle; negative regulation of cytokine production involved in immune response; negative regulation of serotonin secretion; T cell proliferation involved in immune response; negative regulation of alpha-beta T cell activation; negative regulation of T cell mediated cytotoxicity; positive regulation of cytolysis; negative regulation of T cell proliferation; positive regulation of gene expression; defense response to virus; negative regulation of calcium ion transport; regulation of immune response; positive regulation of apoptotic process; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to lipopolysaccharide; immune response-inhibiting cell surface receptor signaling pathway; positive regulation of gamma-delta T cell activation involved in immune response; negative regulation of dendritic cell apoptotic process; negative regulation of dendritic cell differentiation; signal transduction; positive regulation of transcription by RNA polymerase II; negative regulation of CD8-positive, alpha-beta T cell activation; positive regulation of defense response to virus by host; positive regulation of macrophage cytokine production;
	Sources:Amigo / QuickGO
Orthologs
	10859
	n/a
ENSG00000104972; ENSG00000276452; ENSG00000277134; ENSG00000274669; ENSG00000277807;
	n/a
	n/a
	Q8NHL6
	n/a
NM_001081637; NM_001081638; NM_001081639; NM_001278398; NM_001278399;
	NM_006669; NM_001388355; NM_001388356; NM_001388357; NM_001388358
	n/a
NP_001075106; NP_001075107; NP_001075108; NP_001265327; NP_001265328;
	NP_006660
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.^[3]^[4]

^ ^a ^b ^c ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 GRCh38: Ensembl release 89: ENSG00000104972, ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.
^ Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.

[refGRCh38Ensembl-1] ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 GRCh38: Ensembl release 89: ENSG00000104972, ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9285411-3] Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.

[pmid9382880-4] Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.

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