LILRB2

LILRB2
Identifiers
AliasesLILRB2, ILT4, MIR10, LIR2, MIR-10, LIR-2, leukocyte immunoglobulin like receptor B2, ILT-4, CD85D
External IDsOMIM: 604815; HomoloGene: 136797; GeneCards: LILRB2; OMA:LILRB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10288

n/a

Ensembl

n/a

UniProt

A2IXV5

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 54.27 – 54.28 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.[3][4][5]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury.[6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease.[7][8]

  1. ^ a b c ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 GRCh38: Ensembl release 89: ENSG00000274513, ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, et al. (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–1751. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
  4. ^ Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–665. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
  5. ^ a b "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
  6. ^ Mi YJ, Chen H, Guo N, Sun MY, Zhao ZH, Gao XC, et al. (2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging Neuroscience. 9: 199. doi:10.3389/fnagi.2017.00199. PMC 5476690. PMID 28676756.
  7. ^ Lao K, Zhang R, Dai Y, Luan J, Guo N, Xu X, et al. (July 2021). "Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease". Molecular and Cellular Neurosciences. 114: 103630. doi:10.1016/j.mcn.2021.103630. PMID 34029694. S2CID 235203153.
  8. ^ Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, et al. (September 2013). "Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model". Science. 341 (6152): 1399–1404. Bibcode:2013Sci...341.1399K. doi:10.1126/science.1242077. PMC 3853120. PMID 24052308.