LIM2

LIM2
Identifiers
Aliases	LIM2, CTRCT19, MP17, MP19, lens intrinsic membrane protein 2
External IDs	OMIM: 154045; MGI: 104698; HomoloGene: 12744; GeneCards: LIM2; OMA:LIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,387,974 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,085,420 bp
RNA expression pattern
	Top expressed in
	gonad; ; lens; ; granulocyte; ; retinal pigment epithelium; ; blood; ; bone marrow; ; apex of heart; ; placenta; ; lower respiratory tract; ; spleen;
	Top expressed in
	lens; ; embryo; ; morula; ; neural layer of retina; ; blastocyst; ; bone marrow; ; stomach; ; intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of eye lens;
Cellular component	integral component of membrane; vesicle; cell junction; plasma membrane; membrane;
Biological process	camera-type eye development; lens development in camera-type eye; cell-cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	3982
	233187
	ENSG00000105370
	ENSMUSG00000118560
	P55344
	P56563
	NM_030657; NM_001161748
	NM_177693
	NP_001155220; NP_085915
	NP_808361
	Wikidata
View/Edit Human	View/Edit Mouse

Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.^[5]^[6]

The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1; MIM 123660). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD.

This protein appears to contain 4 transmembrane domains, is a substrate for cAMP-dependent protein kinase and protein kinase C, and binds with calmodulin. Taken together, these suggest that MP19 functions in some way as a junctional component, possibly involved with lens cell communication. It has been shown to be involved with cataractogenesis.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105370 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000118560 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Church RL, Wang J (Jul 1992). "Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19". Curr Eye Res. 11 (5): 421–4. doi:10.3109/02713689209001795. PMID 1606837.
^ ^a ^b "Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105370 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000118560 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1606837-5] Church RL, Wang J (Jul 1992). "Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19". Curr Eye Res. 11 (5): 421–4. doi:10.3109/02713689209001795. PMID 1606837.

[entrez-6] "Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa".

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