LIPH (gene)

LIPH
Identifiers
Aliases	LIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDs	OMIM: 607365; MGI: 2388029; HomoloGene: 71802; GeneCards: LIPH; OMA:LIPH - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,552,588 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,814,413 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; rectum; ; pancreatic ductal cell; ; mucosa of transverse colon; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; epithelium of nasopharynx; ; mucosa of ileum; ; mucosa of sigmoid colon;
	Top expressed in
	epithelium of stomach; ; transitional epithelium of urinary bladder; ; lobe of prostate; ; duodenum; ; vestibular membrane of cochlear duct; ; otolith organ; ; ileum; ; utricle; ; right lung lobe; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; carboxylic ester hydrolase activity; hydrolase activity; phospholipase activity; lipase activity;
Cellular component	extracellular region; plasma membrane; membrane; extracellular space;
Biological process	lipid catabolic process; lipid metabolism; phosphatidic acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	200879
	239759
	ENSG00000163898
	ENSMUSG00000044626
	Q8WWY8
	Q8CIV3
	NM_139248
	NM_001083894; NM_001289581; NM_001289582; NM_153404
	NP_640341
	NP_001077363; NP_001276510; NP_001276511; NP_700453
	Wikidata
View/Edit Human	View/Edit Mouse

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.^[5]^[6]^[7]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163898 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
^ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.
^ ^a ^b "Entrez Gene: LIPH lipase, member H".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163898 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044626 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12213196-5] Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.

[pmid12063250-6] Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.

[entrez-7] "Entrez Gene: LIPH lipase, member H".

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