LMX1A

LMX1A
Identifiers
Aliases	LMX1A, LMX1, LMX1.1, LIM homeobox transcription factor 1 alpha, DFNA7
External IDs	OMIM: 600298; MGI: 1888519; HomoloGene: 24921; GeneCards: LMX1A; OMA:LMX1A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,356,715 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,676,310 bp
RNA expression pattern
	Top expressed in
	testicle; ; apex of heart; ; muscle of thigh; ; pituitary gland; ; anterior pituitary; ; gastric mucosa; ; left testis; ; rectum; ; right testis; ; subcutaneous adipose tissue;
	Top expressed in
	choroid plexus of lateral ventricle; ; choroid plexus of fourth ventricle; ; otic vesicle; ; notochord; ; yolk sac; ; neural groove; ; zygote; ; neural fold; ; extraocular muscle; ; neurogenic placodes;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	neuron differentiation; cerebellum development; multicellular organism development; midbrain development; central nervous system development; regulation of transcription, DNA-templated; axon guidance; dentate gyrus development; transcription, DNA-templated; negative regulation of neuron differentiation; central nervous system neuron differentiation; hippocampus development; regulation of cell growth; brain development; dopaminergic neuron differentiation; regulation of gene expression; positive regulation of transcription by RNA polymerase II; synapse organization; olfactory behavior; memory; locomotory behavior; midbrain dopaminergic neuron differentiation; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4009
	110648
	ENSG00000162761
	ENSMUSG00000026686
	Q8TE12
	Q9JKU8
	NM_001033507; NM_001174069; NM_177398; NM_177399
	NM_033652
	NP_001167540; NP_796372
	NP_387501
	Wikidata
View/Edit Human	View/Edit Mouse

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162761 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha".
^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162761 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha".

[pmid7698771-6] German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.

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