LOXL2

LOXL2
Identifiers
Aliases	LOXL2, LOR2, WS9-14, lysyl oxidase like 2, LOR
External IDs	OMIM: 606663; MGI: 2137913; HomoloGene: 1742; GeneCards: LOXL2; OMA:LOXL2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,425,328 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,933,283 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; cartilage tissue; ; tibia; ; gonad; ; adipose tissue; ; smooth muscle tissue; ; muscle layer of sigmoid colon; ; periodontal fiber; ; placenta; ; subcutaneous adipose tissue;
	Top expressed in
	calvaria; ; body of femur; ; ankle joint; ; epithelium of lens; ; ankle; ; stroma of bone marrow; ; migratory enteric neural crest cell; ; external carotid artery; ; cumulus cell; ; dermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; scavenger receptor activity; oligosaccharide binding; protein-lysine 6-oxidase activity; oxidoreductase activity; electron transfer activity; protein binding; copper ion binding; metal ion binding; calcium ion binding;
Cellular component	nucleoplasm; membrane; chromosome; extracellular region; basement membrane; extracellular matrix; extracellular space; chromatin; nucleus; endoplasmic reticulum; collagen-containing extracellular matrix;
Biological process	positive regulation of chondrocyte differentiation; response to hypoxia; collagen fibril organization; epithelial to mesenchymal transition; regulation of transcription, DNA-templated; endothelial cell migration; endothelial cell proliferation; receptor-mediated endocytosis; response to copper ion; cell adhesion; human ageing; negative regulation of transcription, DNA-templated; sprouting angiogenesis; transcription, DNA-templated; electron transport chain; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; peptidyl-lysine oxidation; heterochromatin organization; negative regulation of stem cell population maintenance; chromatin organization; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	4017
	94352
	ENSG00000134013
	ENSMUSG00000034205
	Q9Y4K0
	P58022
	NM_002318
	NM_033325
	NP_002309
	NP_201582
	Wikidata
View/Edit Human	View/Edit Mouse

Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034205 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jourdan-Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K (July 1998). "The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3". Genomics. 51 (2): 305–7. doi:10.1006/geno.1998.5356. PMID 9722957.
^ "Entrez Gene: LOXL2 lysyl oxidase-like 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134013 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034205 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9722957-5] Jourdan-Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K (July 1998). "The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3". Genomics. 51 (2): 305–7. doi:10.1006/geno.1998.5356. PMID 9722957.

[entrez-6] "Entrez Gene: LOXL2 lysyl oxidase-like 2".

[1]

[2]

[3]

[4]

[5]

[6]