LPAR1

LPAR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z34, 4Z35, 4Z36
Identifiers
Aliases	LPAR1, receptor 1, lysophosphatidic acid receptor 1
External IDs	OMIM: 602282; MGI: 108429; HomoloGene: 1072; GeneCards: LPAR1; OMA:LPAR1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	58,553,898 bp
RNA expression pattern
	n/a
	Top expressed in
	maxillary prominence; ; calvaria; ; mandibular prominence; ; optic nerve; ; autopod region; ; hand; ; foot; ; decidua; ; conjunctival fornix; ; utricle;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lysophosphatidic acid binding; PDZ domain binding; G protein-coupled receptor activity; signal transducer activity; protein binding; lysophosphatidic acid receptor activity; G-protein alpha-subunit binding; phospholipid binding; lipid binding;
Cellular component	cytoplasm; integral component of membrane; endosome; membrane; plasma membrane; dendritic spine; endocytic vesicle; integral component of plasma membrane; dendritic shaft; cell surface; soma; neuron projection;
Biological process	positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell chemotaxis; G protein-coupled receptor signaling pathway; neurogenesis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of neuron projection development; positive regulation of cell death; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; bleb assembly; positive regulation of dendritic spine development; activation of phospholipase C activity; cerebellum development; cellular response to 1-oleoyl-sn-glycerol 3-phosphate; brain development; regulation of cell shape; positive regulation of apoptotic process; cell chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; myelination; oligodendrocyte development; corpus callosum development; cellular response to oxygen levels; positive regulation of stress fiber assembly; optic nerve development; positive regulation of MAPK cascade; signal transduction; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	1902
	14745
	ENSG00000198121
	ENSMUSG00000038668
	Q92633
	P61793
	NM_001401; NM_057159
	NM_001290486; NM_010336; NM_172989
NP_001392; NP_476500; NP_001338326; NP_001338327; NP_001338328;
	NP_001338329; NP_001338330; NP_001338331; NP_001338332; NP_001338333; NP_001338334; NP_001338335; NP_001338336; NP_001338337; NP_001338338; NP_001338339; NP_001338340; NP_001338341; NP_001338342; NP_001338343; NP_001338344; NP_001338345; NP_001338346; NP_001338347; NP_001338348; NP_001338349
	NP_001277415; NP_034466; NP_766577
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 1 also known as LPA₁ is a protein that in humans is encoded by the LPAR1 gene.^[4]^[5]^[6] LPA₁ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[7]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038668 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1".
^ Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387.
^ An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000038668 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1".

[pmid8922387-5] Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387.

[pmid9070858-6] An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.

[Choi_2010-7] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[1]

[2]

[3]

[4]

[5]

[6]

[7]