LPAR2

LPAR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P0C
Identifiers
Aliases	LPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs	OMIM: 605110; MGI: 1858422; HomoloGene: 3465; GeneCards: LPAR2; OMA:LPAR2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	19,628,930 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,283,752 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; granulocyte; ; blood; ; right testis; ; spleen; ; left testis; ; monocyte; ; mucosa of transverse colon; ; right lung;
	Top expressed in
	granulocyte; ; yolk sac; ; epiblast; ; tail of embryo; ; otic vesicle; ; genital tubercle; ; ventricular zone; ; ganglion of vagus nerve; ; primitive streak; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; protein binding; lysophosphatidic acid receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of plasma membrane; membrane; endocytic vesicle; integral component of membrane; plasma membrane; cell surface;
Biological process	activation of phospholipase C activity; signal transduction; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9170
	53978
	ENSG00000064547
	ENSMUSG00000031861
	Q9HBW0
	Q9JL06; Q6P290
	NM_004720; NM_001395660
	NM_020028
	NP_004711
	NP_064412
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.^[5]^[6]^[7] LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
^ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
^ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".

[pmid9525886-6] An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.

[pmid9804623-7] An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

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