LPAR6

LPAR6
Identifiers
Aliases	LPAR6, ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6, LPA-6
External IDs	OMIM: 609239; MGI: 1914418; HomoloGene: 55925; GeneCards: LPAR6; OMA:LPAR6 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,444,704 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,480,734 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; monocyte; ; skin of hip; ; minor salivary glands; ; oral cavity; ; vagina; ; granulocyte; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; gallbladder;
	Top expressed in
	hand; ; hair follicle; ; brown adipose tissue; ; medullary collecting duct; ; mammary gland; ; otolith organ; ; utricle; ; skin of abdomen; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; lysophosphatidic acid receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; intracellular membrane-bounded organelle;
Biological process	signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	10161
	67168
	ENSG00000139679
	ENSMUSG00000033446
	P43657
	Q8BMC0
	NM_005767; NM_001162497; NM_001162498; NM_001377316; NM_001377317
	NM_175116
	NP_001155969; NP_001155970; NP_005758; NP_001364245; NP_001364246
	NP_780325
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 6, also known as LPA₆, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene.^[5]^[6]^[7]^[8] LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[9]^[10]

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139679 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033446 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–138. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
^ Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–492. PMID 9755289.
^ Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, et al. (June 2009). "Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6". The Journal of Biological Chemistry. 284 (26): 17731–17741. doi:10.1074/jbc.M808506200. PMC 2719412. PMID 19386608.
^ ^a ^b "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5".
^ Pasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, et al. (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nature Genetics. 40 (3): 329–334. doi:10.1038/ng.84. PMID 18297070. S2CID 20241237.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139679 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033446 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11004484-5] Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–138. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.

[pmid9755289-6] Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–492. PMID 9755289.

[pmid19386608-7] Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, et al. (June 2009). "Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6". The Journal of Biological Chemistry. 284 (26): 17731–17741. doi:10.1074/jbc.M808506200. PMC 2719412. PMID 19386608.

[entrez-8] "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5".

[pmid18297070-9] Pasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, et al. (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nature Genetics. 40 (3): 329–334. doi:10.1038/ng.84. PMID 18297070. S2CID 20241237.

[Choi_2010-10] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]