LRP1

LRP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY
Identifiers
Aliases	LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R
External IDs	OMIM: 107770; MGI: 96828; HomoloGene: 1744; GeneCards: LRP1; OMA:LRP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,128,483 bp[1] End 57,213,361 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,374,030 bp[2] End 127,457,017 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium Descending thoracic aorta ascending aorta right ovary left ovary right coronary artery tibial nerve canal of the cervix sural nerve left coronary artery Top expressed in stroma of bone marrow superior frontal gyrus internal carotid artery external carotid artery ankle primary visual cortex lip choroid plexus of fourth ventricle cerebellar cortex perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding apolipoprotein binding lipoprotein particle receptor binding protein-containing complex binding metal ion binding protease binding protein binding low-density lipoprotein particle receptor activity RNA binding amyloid-beta binding scavenger receptor activity coreceptor activity alpha-2 macroglobulin receptor activity apolipoprotein receptor activity clathrin heavy chain binding signaling receptor activity cargo receptor activity heparan sulfate proteoglycan binding Cellular component integral component of membrane endocytic vesicle membrane endosome membrane focal adhesion receptor complex plasma membrane integral component of plasma membrane lysosomal membrane neuronal cell body dendrite nucleolus clathrin-coated pit clathrin-coated vesicle nucleus cytoplasm cytosol early endosome basolateral plasma membrane insulin-responsive compartment axonal growth cone apical part of cell plasma membrane protein complex Biological process lipoprotein metabolic process negative regulation of neuron apoptotic process negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of neuron projection development endocytosis regulation of actin cytoskeleton organization regulation of phospholipase A2 activity amyloid-beta clearance negative regulation of Wnt signaling pathway human ageing negative regulation of smooth muscle cell migration positive regulation of lipid transport receptor-mediated endocytosis aorta morphogenesis retinoid metabolic process regulation of cholesterol transport positive regulation of protein transport apoptotic cell clearance multicellular organism development protein kinase C-activating G protein-coupled receptor signaling pathway positive regulation of cholesterol efflux cerebral cortex development cell population proliferation lipoprotein transport regulation of extracellular matrix disassembly astrocyte activation involved in immune response lipid metabolism phagocytosis positive regulation of cytosolic calcium ion concentration negative regulation of cell-substrate adhesion positive regulation of cell death positive regulation of neuron projection development receptor internalization positive regulation of protein binding positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of apoptotic process cellular lipid catabolic process transcytosis positive regulation of axon extension positive regulation of endocytosis positive regulation of axon extension involved in regeneration positive regulation of collateral sprouting of injured axon positive regulation of phagocytosis negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of cell death chemoattraction of axon positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance by transcytosis amyloid-beta clearance by cellular catabolic process positive regulation of Schwann cell migration positive regulation of amyloid-beta clearance positive regulation of protein localization to plasma membrane positive regulation of cholesterol import cellular response to amyloid-beta positive regulation of vascular associated smooth muscle cell migration positive regulation of lysosomal protein catabolic process lysosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4035 16971 Ensembl ENSG00000123384 ENSMUSG00000040249 UniProt Q07954 Q91ZX7 RefSeq (mRNA) NM_002332 NM_008512 RefSeq (protein) NP_002323 NP_032538 Location (UCSC) Chr 12: 57.13 – 57.21 Mb Chr 10: 127.37 – 127.46 Mb PubMed search [3] [4]
Wikidata
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Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene.^[5][6][7] LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.^[8][9]