LTBP2

LTBP2
Identifiers
Aliases	LTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3, latent transforming growth factor beta binding protein 2
External IDs	OMIM: 602091; MGI: 99502; HomoloGene: 369; GeneCards: LTBP2; OMA:LTBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,612,378 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,923,306 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; stromal cell of endometrium; ; right coronary artery; ; tendon of biceps brachii; ; saphenous vein; ; pericardium; ; left coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	aortic valve; ; ascending aorta; ; rib; ; stroma of bone marrow; ; vestibular membrane of cochlear duct; ; external carotid artery; ; left lung lobe; ; brown adipose tissue; ; ciliary body; ; calvaria;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; protein binding; growth factor binding; extracellular matrix structural constituent; microfibril binding;
Cellular component	extracellular matrix; extracellular exosome; intracellular anatomical structure; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	protein targeting; transforming growth factor beta receptor signaling pathway; protein secretion; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	4053
	16997
	ENSG00000119681
	ENSMUSG00000002020
	Q14767
	O08999
	NM_000428
	NM_013589; NM_001370743
	NP_000419
	NP_038617; NP_001357672
	Wikidata
View/Edit Human	View/Edit Mouse

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.^[5]^[6]

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins.

It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119681 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.
^ ^a ^b "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119681 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7798248-5] Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.

[entrez-6] "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]