Protein domain
The LU domain (Ly-6 antigen /uPAR ) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins , for example the Ly-6 family, CD59 , and Sgp-2.[ 2] [ 3]
A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved LU domain of about 100 amino-acid residues.[ 4] [ 5] Among these proteins, most contain only a single LU domain, though small numbers of exceptions are known; well-studied family member uPAR has three tandem LU domains.[ 3]
^ PDB : 2J8B ; Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM (August 2007). "High-resolution structures of bacterially expressed soluble human CD59" . Acta Crystallographica. Section F, Structural Biology and Crystallization Communications . 63 (Pt 8): 648–52. doi :10.1107/S1744309107033477 . PMC 2335151 . PMID 17671359 .
^ Kessler P, Marchot P, Silva M, Servent D (August 2017). "The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions" . Journal of Neurochemistry . 142 (Suppl 2): 7–18. doi :10.1111/jnc.13975 . PMID 28326549 .
^ a b Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK (April 2016). "Organization, evolution and functions of the human and mouse Ly6/uPAR family genes" . Human Genomics . 10 : 10. doi :10.1186/s40246-016-0074-2 . PMC 4839075 . PMID 27098205 .
^ Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, Danø K (April 1991). "The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator" . The Journal of Biological Chemistry . 266 (12): 7842–7. doi :10.1016/S0021-9258(20)89526-X . PMID 1850423 .
^ Ploug M, Kjalke M, Rønne E, Weidle U, Høyer-Hansen G, Danø K (August 1993). "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins" . The Journal of Biological Chemistry . 268 (23): 17539–46. doi :10.1016/S0021-9258(19)85366-8 . PMID 8394346 .