LY-255582

LY-255582
Names
	Preferred IUPAC name 3-{(3R,4R)-1-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-3,4-dimethylpiperidin-4-yl}phenol
Identifiers
CAS Number	119193-09-8;
3D model (JSmol)	Interactive image;
ChemSpider	8081850;
PubChem CID	9906198;
CompTox Dashboard (EPA)	DTXSID201045752 ;
	InChI InChI=1S/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1 Key: LVVHEFJXPXAUDD-BULFRSBZSA-N; InChI=1/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1 Key: LVVHEFJXPXAUDD-BULFRSBZBD;
	SMILES C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CC[C@@H](C3CCCCC3)O;
Properties
Chemical formula	C22H35NO2
Molar mass	345.527 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

LY-255582 is a phenylpiperidine non-selective opioid antagonist. It has been shown to reduce ethanol consumption in experiments carried out on rats.^[1] It has also been shown to reduce food and water consumption in rats.^[2]

^ Dhaher R, et al. (Feb 2012). "Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats". Alcohol (Fayetteville, N.Y.). 46 (1): 17–27. doi:10.1016/j.alcohol.2011.08.011. PMC 4581853. PMID 21962974.
^ Shaw WN, et al. (Jun 1991). "The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat". International Journal of Obesity. 15 (6): 387–95. PMID 1653188.

[1] Dhaher R, et al. (Feb 2012). "Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats". Alcohol (Fayetteville, N.Y.). 46 (1): 17–27. doi:10.1016/j.alcohol.2011.08.011. PMC 4581853. PMID 21962974.

[2] Shaw WN, et al. (Jun 1991). "The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat". International Journal of Obesity. 15 (6): 387–95. PMID 1653188.

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