LYPLA1

LYPLA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FJ2
Identifiers
Aliases	LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I, lysophospholipase 1
External IDs	OMIM: 605599; MGI: 1344588; HomoloGene: 100781; GeneCards: LYPLA1; OMA:LYPLA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,102,017 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,918,633 bp
RNA expression pattern
	Top expressed in
	human penis; ; oral cavity; ; gonad; ; vulva; ; right ventricle; ; skin of thigh; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; superior surface of tongue; ; biceps brachii;
	Top expressed in
	right kidney; ; gallbladder; ; superior surface of tongue; ; intercostal muscle; ; jejunum; ; epithelium of small intestine; ; cardiac muscle tissue of left ventricle; ; gastrula; ; extensor digitorum longus muscle; ; plantaris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lysophospholipase activity; hydrolase activity; lipase activity; palmitoyl-(protein) hydrolase activity; carboxylic ester hydrolase activity; protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; mitochondrion;
Biological process	protein depalmitoylation; regulation of nitric-oxide synthase activity; negative regulation of Golgi to plasma membrane protein transport; fatty acid metabolic process; lipid metabolism; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	10434
	18777
	ENSG00000120992
	ENSMUSG00000025903
	O75608; Q6IAQ1
	P97823
NM_001279356; NM_001279357; NM_001279358; NM_001279359; NM_001279360;
	NM_006330
	NM_008866; NM_001355712
NP_001266285; NP_001266286; NP_001266287; NP_001266288; NP_001266289;
	NP_006321; NP_006321.1
	NP_032892; NP_001342641
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.^[5]^[6]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025903 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.
^ ^a ^b "Entrez Gene: LYPLA1 lysophospholipase I".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120992 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025903 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10064899-5] Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.

[entrez-6] "Entrez Gene: LYPLA1 lysophospholipase I".

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