LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.[5][6][7]
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103066 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031903 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M (May 1999). "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase". Biochem Biophys Res Commun. 257 (1): 50–6. doi:10.1006/bbrc.1999.0411. PMID 10092508.
- ^ Schaloske RH, Dennis EA (Nov 2006). "The phospholipase A2 superfamily and its group numbering system". Biochim Biophys Acta. 1761 (11): 1246–59. doi:10.1016/j.bbalip.2006.07.011. PMID 16973413.
- ^ a b "Entrez Gene: LYPLA3 lysophospholipase 3 (lysosomal phospholipase A2)".