Lamin

Not to be confused with Laminin.
For other uses, see Lamin (disambiguation).
Confocal microscopic analysis of a dermal fibroblast in primary culture from a control (a and b) and the subject with HGPS (c and d). Labelling was performed with anti-lamin A/C antibodies. Note the presence of irregularly shaped nuclear envelopes in many of the subject's fibroblasts

Lamins, also known as nuclear lamins are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. Lamins have elastic and mechanosensitive properties, and can alter gene regulation in a feedback response to mechanical cues.[1] Lamins are present in all animals but are not found in microorganisms, plants or fungi.[2][3] Lamin proteins are involved in the disassembling and reforming of the nuclear envelope during mitosis, the positioning of nuclear pores, and programmed cell death. Mutations in lamin genes can result in several genetic laminopathies, which may be life-threatening.

  1. ^ Dutta, S; Bhattacharyya, M; Sengupta, K (14 October 2016). "Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies". Cells. 5 (4): 37. doi:10.3390/cells5040037. PMC 5187521. PMID 27754432.
  2. ^ Dechat, Thomas; Adam, Stephen A.; Taimen, Pekka; Shimi, Takeshi; Goldman, Robert D. (2016-11-24). "Nuclear Lamins". Cold Spring Harbor Perspectives in Biology. 2 (11): a000547. doi:10.1101/cshperspect.a000547. ISSN 1943-0264. PMC 2964183. PMID 20826548.
  3. ^ Hardin Jeff, and Bertoni Gregory (2016). Becker's World of the Cell, 9th Edition. Boston, MA: Pearson. ISBN 9780321934925.