Lamin B receptor

LBR
Available structures
PDB	Ortholog search: C9JXK0 PDBe C9JXK0 RCSB
List of PDB id codes
	2DIG
Identifiers
Aliases	LBR, DHCR14B, LMN2R, PHA, TDRD18, lamin B receptor, PHASK, C14SR
External IDs	OMIM: 600024; MGI: 2138281; HomoloGene: 2455; GeneCards: LBR; OMA:LBR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,428,925 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	181,670,611 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; thymus; ; bone marrow cells; ; ventricular zone; ; muscle layer of sigmoid colon; ; seminal vesicula; ; appendix; ; visceral pleura; ; mononuclear cell;
	Top expressed in
	tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; granulocyte; ; mesenteric lymph nodes; ; human fetus; ; thymus; ; abdominal wall; ; hair follicle; ; primitive streak; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; DNA binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; protein binding; chromo shadow domain binding; lamin binding; delta14-sterol reductase activity; RNA binding; NADPH binding; oxidoreductase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; nuclear inner membrane; integral component of nuclear inner membrane; nuclear membrane; nuclear envelope; membrane; nucleus; cytoplasm; endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	cholesterol biosynthetic process; sterol biosynthetic process; neutrophil differentiation; lipid metabolism; steroid biosynthetic process; steroid metabolic process; cholesterol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3930
	98386
	ENSG00000143815
	ENSMUSG00000004880
	Q14739
	Q3U9G9
	NM_002296; NM_194442
	NM_133815
	NP_002287; NP_919424
	NP_598576
	Wikidata
View/Edit Human	View/Edit Mouse

Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143815 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schuler E, Lin F, Worman HJ (April 1994). "Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane". The Journal of Biological Chemistry. 269 (15): 11312–7. doi:10.1016/S0021-9258(19)78127-7. PMID 8157663.
^ Holmer L, Pezhman A, Worman HJ (December 1998). "The human lamin B receptor/sterol reductase multigene family". Genomics. 54 (3): 469–76. doi:10.1006/geno.1998.5615. PMID 9878250.
^ "Entrez Gene: LBR lamin B receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143815 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8157663-5] Schuler E, Lin F, Worman HJ (April 1994). "Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane". The Journal of Biological Chemistry. 269 (15): 11312–7. doi:10.1016/S0021-9258(19)78127-7. PMID 8157663.

[pmid9878250-6] Holmer L, Pezhman A, Worman HJ (December 1998). "The human lamin B receptor/sterol reductase multigene family". Genomics. 54 (3): 469–76. doi:10.1006/geno.1998.5615. PMID 9878250.

[entrez-7] "Entrez Gene: LBR lamin B receptor".

[1]

[2]

[3]

[4]

[5]

[6]

[7]