Laminin, alpha 5

LAMA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y38
Identifiers
Aliases	LAMA5, Laminin, alpha 5, laminin subunit alpha 5
External IDs	OMIM: 601033; MGI: 105382; HomoloGene: 4060; GeneCards: LAMA5; OMA:LAMA5 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	62,367,312 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,867,652 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; right lung; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; gastric mucosa; ; upper lobe of left lung; ; skin of abdomen;
	Top expressed in
	gastrula; ; decidua; ; ascending aorta; ; medullary collecting duct; ; left lung lobe; ; epiblast; ; blastocyst; ; molar; ; aortic valve; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; integrin binding; signaling receptor binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; laminin-5 complex; extracellular region; basement membrane; laminin-10 complex; laminin-11 complex; extracellular exosome; nucleus; extracellular space; synaptic cleft; neuromuscular junction; collagen-containing extracellular matrix;
Biological process	hair follicle development; cell differentiation; regulation of embryonic development; regulation of cell migration; cell recognition; embryo development; lung development; muscle organ development; extracellular matrix organization; morphogenesis of a polarized epithelium; odontogenesis of dentin-containing tooth; focal adhesion assembly; branching involved in ureteric bud morphogenesis; regulation of cell adhesion; cell adhesion; regulation of cell population proliferation; cytoskeleton organization; angiogenesis; neural crest cell migration; animal organ morphogenesis; integrin-mediated signaling pathway; endothelial cell differentiation; substrate adhesion-dependent cell spreading; morphogenesis of embryonic epithelium; cell population proliferation; cell migration; branching morphogenesis of an epithelial tube; branching involved in salivary gland morphogenesis; cilium assembly; protein localization to plasma membrane; cytokine-mediated signaling pathway; tissue development; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3911
	16776
	ENSG00000130702
	ENSMUSG00000015647
	O15230
	Q61001
	NM_005560
	NM_001081171
	NP_005551
	NP_001074640
	Wikidata
View/Edit Human	View/Edit Mouse

Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130702 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015647 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM (Jul 1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Letters. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224. S2CID 45286880.
^ "Entrez Gene: LAMA5 laminin, alpha 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130702 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015647 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9271224-5] Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM (Jul 1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Letters. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224. S2CID 45286880.

[entrez-6] "Entrez Gene: LAMA5 laminin, alpha 5".

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