Langerhans cell

Not to be confused with the cells of the islets of Langerhans in the pancreas, or Langhans giant cell.
Langerhans cell
Section of skin showing large numbers of Langerhans cells in the epidermis. (M. ulcerans infection, S100 immunoperoxidase stain.)
Details
SystemImmune system
LocationSkin and mucosa
FunctionDendritic cell
Identifiers
MeSHD007801
FMA63072
Anatomical terms of microanatomy
The representation of Langerhans cells in the Cell Ontology. A portion of the Cell Ontology is shown with ovals corresponding to cell types defined in the ontology and arrows corresponding to relations between those cell types. Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations. Only a subset of Langerhans cell parent types are included in the figure.[1]

A Langerhans cell (LC) is a tissue-resident macrophage of the skin[2] once thought to be a resident dendritic cell.[3] These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum.[4] They also occur in the papillary dermis, particularly around blood vessels,[4] as well as in the mucosa of the mouth, foreskin, and vaginal epithelium.[5] They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH).

  1. ^ Masci, Anna; Arighi, Cecilia N; Diehl, Alexander D; Lieberman, Anne E; Mungall, Chris; Scheuermann, Richard H; Smith, Barry; Cowell, Lindsay G (2009). "An improved ontological representation of dendritic cells as a paradigm for all cell types". BMC Bioinformatics. 10: 70. doi:10.1186/1471-2105-10-70. PMC 2662812. PMID 19243617.
  2. ^ Doebel, T.; Voisin, B.; Nagao, K. (2017). "Langerhans Cells – The Macrophage in Dendritic Cell Clothing". Trends in Immunology. 38 (11): 817–828. doi:10.1016/j.it.2017.06.008. PMID 28720426.
  3. ^ "MeSH Browser".
  4. ^ a b Young, Barbara; Heath, John W. (2000). Wheater's Functional Histology (4th ed.). Churchill Livingstone. p. 162. ISBN 0-443-05612-9.
  5. ^ Cite error: The named reference pmid7558138 was invoked but never defined (see the help page).