Laser Doppler imaging

Laser Doppler imaging
Microangiography of the optic disc region of the human retina, by laser Doppler imaging. The image was rendered computationally by optical wave propagation and measurement of optical fluctuations.
Purposemeasure blood flow in eye
Based onDigital holography

Laser Doppler imaging (LDI) is an imaging method that uses a laser beam to image live tissue. When the laser light reaches the tissue, the moving blood cells generate Doppler components in the reflected (backscattered) light. The light that comes back is detected using a photodiode that converts it into an electrical signal. Then the signal is processed to calculate a signal that is proportional to the tissue perfusion in the imaged area. When the process is completed, the signal is processed to generate an image that shows the perfusion on a screen.[1]

The laser Doppler effect was first used to measure microcirculation by Stern M.D. in 1975.[2][3] It is used widely in medicine, some representative research work about it are these: [4][5][6]

  1. ^ Wardell, K.; Jakobsson, A.; Nilsson, G.E. (1993). "Laser Doppler perfusion imaging by dynamic light scattering". IEEE Transactions on Biomedical Engineering. 40 (4): 309–316. doi:10.1109/10.222322. PMID 8375866. S2CID 23260143.
  2. ^ Leahy, M.J.; de Mul, F.F.M.; Nilsson, G.E.; Maniewski, R. (1999-06-01). "Principles and practice of the laser-Doppler perfusion technique" (PDF). Technology and Health Care. 7 (2–3): 143–162. doi:10.3233/THC-1999-72-306. PMID 10463304.
  3. ^ Stern, M. D. (March 1975). "In vivo evaluation of microcirculation by coherent light scattering". Nature. 254 (5495): 56–58. Bibcode:1975Natur.254...56S. doi:10.1038/254056a0. PMID 1113878. S2CID 4181767.
  4. ^ Leutenegger, Marcel; Martin-Williams, Erica; Harbi, Pascal; Thacher, Tyler; Raffoul, Wassim; André, Marc; Lopez, Antonio; Lasser, Philippe; Lasser, Theo (2011-06-01). "Real-time full field laser Doppler imaging". Biomedical Optics Express. 2 (6): 1470–1477. doi:10.1364/BOE.2.001470. PMC 3114216. PMID 21698011.
  5. ^ Grothusen, John R.; Schwartzman, Robert J. (September 2011). "Laser Doppler imaging: usefulness in chronic pain medicine". Pain Physician. 14 (5): 491–498. doi:10.36076/ppj.2011/14/491. PMID 21927054.
  6. ^ Clark, Stuart; Campbell, Fiona; Moore, Tonia; Jayson, Malcolm I.V.; King, Terence A.; Herrick, Ariane L. (1999-05-01). "Laser Doppler Imaging—A New Technique for Quantifying Microcirculatory Flow in Patients with Primary Raynaud's Phenomenon and Systemic Sclerosis". Microvascular Research. 57 (3): 284–291. doi:10.1006/mvre.1998.2124. PMID 10329254.