Latrophilin 1

ADGRL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JX9, 2JXA
Identifiers
Aliases	ADGRL1, CIRL1, CL1, LEC2, LPHN1, adhesion G protein-coupled receptor L1
External IDs	OMIM: 616416; MGI: 1929461; HomoloGene: 8951; GeneCards: ADGRL1; OMA:ADGRL1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,206,187 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	83,941,954 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; Brodmann area 9; ; hippocampus proper; ; temporal lobe;
	Top expressed in
	CA3 field; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; nucleus accumbens; ; primary motor cortex; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; cell adhesion molecule binding; carbohydrate binding; latrotoxin receptor activity;
Cellular component	integral component of membrane; cell projection; membrane; growth cone; plasma membrane; synapse; cell junction; axon; neuron projection; presynaptic membrane; intracellular anatomical structure; integral component of plasma membrane; postsynaptic density;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; signal transduction; positive regulation of synapse assembly; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of synapse maturation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	22859
	330814
	ENSG00000072071; ENSG00000288324
	ENSMUSG00000013033
	O94910
	Q80TR1
	NM_001008701; NM_014921
	NM_181039
	NP_001008701; NP_055736
	NP_851382
	Wikidata
View/Edit Human	View/Edit Mouse

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene.^[5]^[6] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]^[8]^[9]

^ ^a ^b ^c ENSG00000288324 GRCh38: Ensembl release 89: ENSG00000072071, ENSG00000288324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
^ "Entrez Gene: LPHN1 latrophilin 1".
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[refGRCh38Ensembl-1] ENSG00000288324 GRCh38: Ensembl release 89: ENSG00000072071, ENSG00000288324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10994649-5] Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.

[entrez-6] "Entrez Gene: LPHN1 latrophilin 1".

[isbn1-4419-7912-3-7] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid12435584-8] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[pmid22333914-9] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

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