Latrophilin 2

ADGRL2
Identifiers
AliasesADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
External IDsOMIM: 607018; MGI: 2139714; HomoloGene: 22712; GeneCards: ADGRL2; OMA:ADGRL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081298

RefSeq (protein)
Location (UCSC)Chr 1: 81.31 – 81.99 MbChr 3: 148.82 – 148.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.[5][6]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117114Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028184Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
  6. ^ a b "Entrez Gene: LPHN2 latrophilin 2".