Lattice light-sheet microscopy

Lattice light-sheet microscopy is a modified version of light sheet fluorescence microscopy that increases image acquisition speed while decreasing damage to cells caused by phototoxicity. This is achieved by using a structured light sheet to excite fluorescence in successive planes of a specimen, generating a time series of 3D images which can provide information about dynamic biological processes.[1][2]

It was developed in the early 2010s by a team led by Eric Betzig.[1] According to an interview conducted by The Washington Post, Betzig believes that this development will have a greater impact than the work that earned him the 2014 Nobel Prize in Chemistry for "the development of super-resolution fluorescence microscopy".[3]

  1. ^ a b Cite error: The named reference ScienceBetzig was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Keely was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference washingtonpost.com was invoked but never defined (see the help page).