Lefty (protein)

left-right determination factor 2
left-right determination factor 2
Identifiers
Symbol	LEFTY2
Alt. symbols	TGFB4, EBAF
NCBI gene	7044
HGNC	3122
OMIM	601877
RefSeq	NM_003240
UniProt	O00292
Other data
Locus	Chr. 1 q42.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

left-right determination factor 1
left-right determination factor 1
Identifiers
Symbol	LEFTY1
Alt. symbols	LEFTB
NCBI gene	10637
HGNC	6552
OMIM	603037
RefSeq	NM_020997
UniProt	O75610
Other data
Locus	Chr. 1 q42.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Lefty (left-right determination factors) are a class of proteins that are closely related members of the TGF-beta superfamily of growth factors. These proteins are secreted and play a role in left-right asymmetry determination of organ systems during development.^[1] Mutations of the genes encoding these proteins have been associated with left-right axis malformations, particularly in the heart and lungs.^[2]

^ Cite error: The named reference pmid11836504 was invoked but never defined (see the help page).
^ Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H (August 1998). "lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal". Cell. 94 (3): 287–97. doi:10.1016/S0092-8674(00)81472-5. PMID 9708731. S2CID 5666974.

[pmid11836504-1] Cite error: The named reference pmid11836504 was invoked but never defined (see the help page).

[pmid9708731-2] Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H (August 1998). "lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal". Cell. 94 (3): 287–97. doi:10.1016/S0092-8674(00)81472-5. PMID 9708731. S2CID 5666974.

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