Leronlimab

Leronlimab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetCCR5
Clinical data
Other namesPRO 140
ATC code
  • none
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
NIAID ChemDB
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Leronlimab (codenamed PRO 140) is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system. It is being investigated as a potential therapy in the treatment of COVID-19,[1][2] triple negative breast cancer,[3] and HIV infection.[4] The United States Food and Drug Administration has designated PRO 140 for fast-track approval.[5] In February 2008, the drug entered Phase 2 clinical trials and a phase 3 trial was begun in 2015.[6][7] In February 2018, Cytodyn Inc reported that the primary endpoint had been achieved in the PRO 140 pivotal combination therapy trial in HIV infection.[8] In 2020 CytoDyn submitted a fast-track biologics license application for treatment of CCR5-tropic HIV-1 Infection.[9]

  1. ^ Clinical trial number NCT04343651 for "Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19" at ClinicalTrials.gov
  2. ^ "Study to Evaluate the Efficacy and Safety of Leronlimab for Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)". ClinicalTrials.gov. Retrieved 14 August 2020.
  3. ^ Clinical trial number NCT03838367 for "Leronlimab (PRO 140) Combined With Carboplatin in Patients With CCR5+ mTNBC " at ClinicalTrials.gov
  4. ^ "CytoDyn Announces Acquisition of PRO 140". CytoDyn Inc. October 17, 2012. Archived from the original on September 25, 2013. Retrieved December 18, 2012.
  5. ^ Lawler B (2 May 2007). "Progenics' Intriguing Study Results". The Motley Fool.
  6. ^ "Phase 2 clinical trials started on PRO 140". AIDS Patient Care and STDs. 22 (2): 159–160. February 2008. doi:10.1089/apc.2008.9960. PMID 18273941.
  7. ^ "Cytodyn Initiates First Clinical Site for Phase 3 Trial of PRO 140 :: CytoDyn Inc. (CYDY)". www.cytodyn.com (Press release). Retrieved 2015-08-22.
  8. ^ "CytoDyn Reports Primary Endpoint Achieved in PRO 140 Pivotal Combination Therapy Trial in HIV Infection :: CytoDyn Inc. (CYDY)". www.cytodyn.com (Press release). Retrieved 2018-04-19.
  9. ^ "CytoDyn Receives BLA Acknowledgment Letter From the FDA". CytoDyn Inc. (Press release). Retrieved 2020-08-14.