Leukemia inhibitory factor

LIF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EMR, 1PVH, 2Q7N
Identifiers
Aliases	LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, interleukin 6 family cytokine, LIF interleukin 6 family cytokine
External IDs	OMIM: 159540; MGI: 96787; HomoloGene: 1734; GeneCards: LIF; OMA:LIF - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,240,453 bp[1] End 30,246,759 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 2.94 cM Start 4,207,557 bp[2] End 4,222,514 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue gallbladder beta cell vena cava mucosa of urinary bladder appendix pancreatic ductal cell mucosa of transverse colon smooth muscle tissue mucosa of paranasal sinus Top expressed in endometrium Glandular part of endometrium mucous gland blastocyst morula lip granulocyte stroma of bone marrow yolk sac esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding growth factor activity cytokine activity protein binding leukemia inhibitory factor receptor binding Cellular component extracellular region extracellular space cytosol Biological process negative regulation of cell population proliferation stem cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of MAPK cascade positive regulation of peptidyl-serine phosphorylation spongiotrophoblast differentiation lung development positive regulation of histone H3-K27 acetylation multicellular organism development lung lobe morphogenesis muscle organ morphogenesis maternal process involved in female pregnancy negative regulation of hormone secretion leukemia inhibitory factor signaling pathway regulation of metanephric nephron tubule epithelial cell differentiation regulation of cell differentiation positive regulation of gene expression stem cell population maintenance positive regulation of peptidyl-tyrosine phosphorylation regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of astrocyte differentiation negative regulation of ERK1 and ERK2 cascade neuron development decidualization positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis lung alveolus development positive regulation of macrophage differentiation blood vessel remodeling trophoblast giant cell differentiation lung vasculature development positive regulation of transcription by RNA polymerase II positive regulation of protein localization to nucleus embryo implantation negative regulation of meiotic nuclear division immune response positive regulation of cell population proliferation positive regulation of tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein regulation of signaling receptor activity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3976 16878 Ensembl ENSG00000128342 ENSMUSG00000034394 UniProt P15018 P09056 RefSeq (mRNA) NM_001257135 NM_002309 NM_001039537 NM_008501 RefSeq (protein) NP_001244064 NP_002300 NP_001034626 NP_032527 Location (UCSC) Chr 22: 30.24 – 30.25 Mb Chr 11: 4.21 – 4.22 Mb PubMed search [3] [4]
Wikidata
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Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.