Levamlodipine

Levamlodipine
Clinical data
Trade namesConjupri, others
AHFS/Drugs.comMonograph
License data
Routes of
administration		Oral
ATC code
Pharmacokinetic data
Protein binding93%
MetabolismLiver
Excretion60% of the metabolites excreted in the urine
Identifiers
  • (S)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H25ClN2O5
Molar mass408.88 g·mol−1
3D model (JSmol)
  • Clc1ccccc1[C@H]2C(=C(/N/C(=C2/C(=O)OCC)COCCN)C)\C(=O)OC
  • InChI=InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1 checkY
  • Key:HTIQEAQVCYTUBX-KRWDZBQOSA-N checkY

Levamlodipine (INN), also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine.[1] Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent.[2] It was approved by the U.S. FDA in December 2019 and is currently marketed under the brand name Conjupri.[3]

  1. ^ Bhandari P, Shah C, Surwade S (2008-01-01), Chirality-Today and Tomorrow's Way of Treatment, retrieved 2021-10-22
  2. ^ Thacker HP (April 2007). "S-amlodipine--the 2007 clinical review". Journal of the Indian Medical Association. 105 (4): 180–2, 184, 186 passim. PMID 17822186.
  3. ^ "Levamlodipine maleate". FDA-Approved Drugs. U.S. Food and Drug Administration.