Lewis Henry Little | |
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| Born | March 19, 1817 Baltimore, Maryland |
| Died | September 19, 1862 (aged 45) Iuka, Mississippi |
| Place of burial | Green Mount Cemetery Baltimore, Maryland |
| Allegiance |  United States of America Confederate States of America |
| Service |  United States Army Confederate States Army |
| Years of service | 1839–61 (USA) 1861–62 (CSA) |
| Rank |  Captain (USA)Brigadier General (CSA) |
| Commands | 1st Missouri Brigade 1st Division, Army of the West |
| Battles / wars | Mexican-American War |
| Relations | brother-in-law of Alexander E. Steen |
Lewis Henry Little (March 19, 1817 – September 19, 1862) was a career United States Army officer and a Confederate brigadier general during the American Civil War. He served mainly in the Western Theater and was killed in action during the Battle of Iuka.