| Linitis plastica | |
|---|---|
| Other names | Leather bottle stomach |
 | |
| Endoscopic image of linitis plastica, where the entire stomach is invaded with stomach cancer, leading to a leather bottle like appearance | |
| Specialty | Oncology  |
Linitis plastica (sometimes referred to as leather bottle stomach) is a morphological variant of diffuse stomach cancer in which the stomach wall becomes thick and rigid.[1]
Linitis plastica is a type of adenocarcinoma and accounts for 3–19% of gastric adenocarcinomas.[1] Causes of cancerous linitis plastica are commonly primary gastric cancer, but in rarer cases could be metastatic infiltration of the stomach, particularly breast and lung carcinoma.[2] It is not associated with H. pylori infection or chronic gastritis. The risk factors are undefined, except for rare inherited mutations in E-cadherin. The hereditary form of this cancer, hereditary diffuse gastric cancer, accounts for only 1–3% of gastric adenocarcinomas. Somatic mutations in this gene are found in about 50% of diffuse-type gastric carcinomas.[2]
- ^ a b Jafferbhoy S, Shiwani H, Rustum Q (2013). "Managing Gastric Linitis Plastica: Keep the scalpel sheathed". Sultan Qaboos Univ Med J. 13 (3): 451–3. doi:10.12816/0003269. PMC 3749031. PMID 23984032.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Robbins Basic Pathology, 8th Edition