Linzagolix

Linzagolix
Clinical data
Pronunciation/ˌlɪnzəˈɡoʊlɪks/
LINZ-ə-GOH-liks
Trade namesYselty
Other namesKLH-2109; OBE-2109
Routes of
administration		By mouth[1][2]
Drug classGnRH modulator; GnRH antagonist; Antigonadotropin
ATC code
Legal status
Legal status
Identifiers
  • 3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC22H15F3N2O7S
Molar mass508.42 g·mol−1
3D model (JSmol)
  • COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1OCc1c(OC)ccc(F)c1F
  • InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)18(25)9(14)7-34-16-6-13(11(24)5-15(16)33-2)27-20(28)17-12(26-22(27)31)8-35-19(17)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30)
  • Key:BMAAMIIYNNPHAB-UHFFFAOYSA-N

Linzagolix, sold under the brand name Yselty, is a medication used in the treatment of uterine fibroids.[1][5] Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) developed by Kissei Pharmaceutical and ObsEva.[6][7][2]

In June 2022, it was approved for medical use in the European Union and in the United Kingdom.[1][4][8]

  1. ^ a b c d "Yselty EPAR". European Medicines Agency (EMA). 14 December 2021. Retrieved 19 August 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  2. ^ a b Ezzati M, Carr BR (January 2015). "Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain". Women's Health. 11 (1): 19–28. doi:10.2217/whe.14.68. PMID 25581052.
  3. ^ "Linzagolix". Specialist Pharmacy Service. 8 August 2022. Retrieved 24 August 2022.
  4. ^ a b "Yselty Product information". European Commission. EU/1/21/1606. Retrieved 24 June 2022.
  5. ^ "Yselty film-coated tablets" (PDF). Theramex Ireland Limited. European Medicines Agency.
  6. ^ "Linzagolix - Kissei Pharmaceutical/ObsEva". AdisInsight. Springer Nature Switzerland AG.
  7. ^ Chodankar R, Allison J (2018). "New Horizons in Fibroid Management". Current Obstetrics and Gynecology Reports. 7 (2): 106–115. doi:10.1007/s13669-018-0242-6. ISSN 2161-3303.
  8. ^ Cite error: The named reference ObsEva2022 was invoked but never defined (see the help page).