 | This article needs attention from an expert in biochemistry. The specific problem is: "Nowhere on Wikipedia, not even here, triglyceride synthesis is described in detail, whereas fatty acid synthesis is fully described elsewhere". (July 2018) |
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat.[1] Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). Fatty acids are produced in the cytoplasm of cells by repeatedly adding two-carbon units to acetyl-CoA. Triacylglycerol synthesis, on the other hand, occurs in the endoplasmic reticulum membrane of cells by bonding three fatty acid molecules to a glycerol molecule. Both processes take place mainly in liver and adipose tissue. Nevertheless, it also occurs to some extent in other tissues such as the gut and kidney.[2][3] A review on lipogenesis in the brain was published in 2008 by Lopez and Vidal-Puig.[4] After being packaged into VLDL in the liver, the resulting lipoprotein is then secreted directly into the blood for delivery to peripheral tissues.
- ^ Kersten S (April 2001). "Mechanisms of nutritional and hormonal regulation of lipogenesis". EMBO Rep. 2 (4): 282–6. doi:10.1093/embo-reports/kve071. PMC 1083868. PMID 11306547.
- ^ Hoffman, Simon; Alvares, Danielle; Adeli, Khosrow (2019). "Intestinal lipogenesis: how carbs turn on triglyceride production in the gut". Current Opinion in Clinical Nutrition and Metabolic Care. 22 (4): 284–288. doi:10.1097/MCO.0000000000000569. ISSN 1473-6519. PMID 31107259. S2CID 159039179.
- ^ Figueroa-Juárez, Elizabeth; Noriega, Lilia G.; Pérez-Monter, Carlos; Alemán, Gabriela; Hernández-Pando, Rogelio; Correa-Rotter, Ricardo; Ramírez, Victoria; Tovar, Armando R.; Torre-Villalvazo, Iván; Tovar-Palacio, Claudia (2021-01-07). "The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice". Biomolecules. 11 (1): 73. doi:10.3390/biom11010073. ISSN 2218-273X. PMC 7825661. PMID 33430288.
- ^ López, Miguel; Vidal-Puig, Antonio (2008). "Brain lipogenesis and regulation of energy metabolism". Current Opinion in Clinical Nutrition and Metabolic Care. 11 (4): 483–490. doi:10.1097/MCO.0b013e328302f3d8. ISSN 1363-1950. PMID 18542011. S2CID 40680910.