Protein-coding gene in the species Homo sapiens
PLA2G7 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D59 , 3D5E , 3F96 , 3F97 , 3F98 , 3F9C , 5JAU , 5JAR , 5I9I , 5JAD , 5JAO , 5I8P , 5JAS , 5JAN , 5JAL , 5JAH , 5JAP , 5JAT
Identifiers Aliases PLA2G7 , LDL-PLA2, LP-PLA2, PAFAD, PAFAH, Lipoprotein-associated phospholipase A2, phospholipase A2 group VIIExternal IDs OMIM : 601690 ; MGI : 1351327 ; HomoloGene : 3725 ; GeneCards : PLA2G7 ; OMA :PLA2G7 - orthologs Wikidata
Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) also known as platelet-activating factor acetylhydrolase (PAF-AH ) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene .[ 5] [ 6] Lp-PLA2 is a 45-kDa protein of 441 amino acids .[ 7] It is one of several PAF acetylhydrolases .
^ a b c GRCh38: Ensembl release 89: ENSG00000146070 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023913 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, et al. (April 1995). "Anti-inflammatory properties of a platelet-activating factor acetylhydrolase". Nature . 374 (6522): 549–53. Bibcode :1995Natur.374..549T . doi :10.1038/374549a0 . PMID 7700381 . S2CID 4338858 .
^ Tew DG, Southan C, Rice SQ, Lawrence MP, Li H, Boyd HF, et al. (April 1996). "Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins". Arteriosclerosis, Thrombosis, and Vascular Biology . 16 (4): 591–9. doi :10.1161/01.ATV.16.4.591 . PMID 8624782 .
^ Zalewski A, Macphee C (May 2005). "Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target" . Arteriosclerosis, Thrombosis, and Vascular Biology . 25 (5): 923–31. doi :10.1161/01.ATV.0000160551.21962.a7 . PMID 15731492 . S2CID 5778538 .