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Trade names | Zefnart |
Other names | M-732; piritetrate |
Routes of administration | Topical |
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Formula | C18H20N2O2S |
Molar mass | 328.43 g·mol−1 |
Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3][4]
Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.[5]