Lisette G. de Pillis is an American mathematician at Harvey Mudd College and holds the Norman F. Sprague, Jr. Professorship of Life Sciences at Harvey Mudd.[1] She chaired the Department of Mathematics in 2008-2009 and again from 2014 to 2019. She directed the Harvey Mudd College Global Clinic program from 2009 to 2014. She is also the co-director of the Harvey Mudd College Center for Quantitative Life Sciences.[2]