This article lists the people who have been fatally injured in American Championship car racing during testing, practice, qualifying, or races since 1916, categorized into drivers, riding mechanics, and non-participants. The lists recognize "IndyCar" or "Champ Car" fatalities that have occurred in events making up the National Championship, which has been held by the following sanctioning bodies:
The National Championship, which was split from 1979 to 2007, has featured regular races, non-points paying (non-championship) rounds, competitions sanctioned by entities that did not stage the National Championship in the same year (such as the Automobile Club of America), and the AAA Big car meetings held in the 1946 season.
The most recent driver to be fatally injured in an IndyCar Series event was Justin Wilson at the 2015 ABC Supply 500.