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The Trigun anime and manga series features a cast of characters created by Yasuhiro Nightow. It takes place in a western/steampunk setting, primarily on a fictional desert planet where humanity has settled after leaving Earth, where civilization is sparse and mostly lawless. The plot and characters of the series differ greatly between the original manga and its anime adaptation, with the anime following roughly up to the second volume of the manga before diverging into a unique telling of the story. The series' story follows the adventures of Vash the Stampede, a legendary gunman who aims to spread his message of love and peace while combating his brother Millions Knives and Legato Bluesummers.
The protagonist of the series is Vash, a jovial, pacifist gunman who is followed by disaster and misfortune due to the large bounty on his head. Early on in the series, he is pursued by Meryl Stryfe and Milly Thompson, insurance agents assigned with evaluating damages involving him. He also meets Nicholas D. Wolfwood, a violent and serious traveling preacher who becomes his strongest ally and friend. Throughout the series, Vash interacts with and befriends many people across the globe. Opposing him and his companions is his twin brother Millions Knives, who hates humans and his way of life. Closely following Knives is Legato Bluesummers, a cold and powerful man who is the leader of the Gung-Ho Guns, a group of super-powered assassins.