The Little Conemaugh River is a tributary of the Conemaugh River, approximately 30 miles (48 km) long, in western Pennsylvania in the United States.
The main branch rises in eastern Cambria County, along the western slope of the Appalachian ridge separating the watersheds of the Ohio and Susquehanna rivers. It flows west-southwest through the mountains, past Cassandra, Portage, and Summerhill, where it is joined by the South Fork Little Conemaugh River. It then follows a west-northwest course to Johnstown, where it joins the Stonycreek River to form the Conemaugh River.