Liver sinusoid

Liver sinusoid
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm.
Basic liver structure
Details
Drains fromHepatic portal vein
Drains toCentral veins of liver
Identifiers
Latinvas sinusoideum
THH3.04.05.0.00014
FMA17543
Anatomical terminology

A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.[1]

The liver sinusoid has a larger caliber than other types of capillaries and has a lining of specialised endothelial cells known as the liver sinusoidal endothelial cells (LSECs), and Kupffer cells.[2] The cells are porous and have a scavenging function.[3] The LSECs make up around half of the non-parenchymal cells in the liver and are flattened and fenestrated.[4] LSECs have many fenestrae that gives easy communication between the sinusoidal lumen and the space of Disse. They play a part in filtration, endocytosis, and in the regulation of blood flow in the sinusoids.[5]

The Kupffer cells can take up and destroy foreign material such as bacteria. Hepatocytes are separated from the sinusoids by the space of Disse. Hepatic stellate cells are present in the space of Disse and are involved in scar formation in response to liver damage.

Defenestration happens when LSECs are lost rendering the sinusoid as an ordinary capillary. This process precedes fibrosis.[6]

  1. ^ SIU SOM Histology GI
  2. ^ Brunt, EM; et al. (June 2014). "Pathology of the liver sinusoids". Histopathology. 64 (7): 907–20. doi:10.1111/his.12364. PMID 24393125. S2CID 12709169.
  3. ^ DeLeve, LD (November 2007). "Hepatic microvasculature in liver injury". Seminars in Liver Disease. 27 (4): 390–400. doi:10.1055/s-2007-991515. PMID 17979075.
  4. ^ Xing, Y; Zhao, T; Gao, X; Wu, Y (18 February 2016). "Liver X receptor α is essential for the capillarization of liver sinusoidal endothelial cells in liver injury". Scientific Reports. 6: 21309. Bibcode:2016NatSR...621309X. doi:10.1038/srep21309. PMC 4758044. PMID 26887957.
  5. ^ Arii, S; Imamura, M (2000). "Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury". Journal of Hepato-biliary-pancreatic Surgery. 7 (1): 40–8. doi:10.1007/s005340050152. PMID 10982590.
  6. ^ Xie, G; Wang, X; Wang, L; Wang, L; Atkinson, RD; Kanel, GC; Gaarde, WA; Deleve, LD (April 2012). "Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats". Gastroenterology. 142 (4): 918–927.e6. doi:10.1053/j.gastro.2011.12.017. PMC 3618963. PMID 22178212.