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Luis Agote (September 22, 1868 – November 12, 1954) was an Argentine physician and researcher. He was the first to perform a non-direct blood transfusion using sodium citrate as an anticoagulant.[1] The procedure took place in Rawson hospital in the city of Buenos Aires on November 9, 1914. Agote was the first to perform this procedure in the Americas. Agote worked independently and separately from the Belgian surgeon Albert Hustin, who discovered that sodium citrate in tolerable quantities could anticoagulate blood for transfusion on March 27, 1914.