Luteinizing hormone/choriogonadotropin receptor

LHCGR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 7FIG, 7FIH, 7FII, 7FIJ
Identifiers
Aliases	LHCGR, HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5, Luteinizing hormone/choriogonadotropin receptor
External IDs	OMIM: 152790; MGI: 96783; HomoloGene: 37276; GeneCards: LHCGR; OMA:LHCGR - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.3 Start 48,686,774 bp[1] End 48,755,730 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E4|17 58.35 cM Start 89,023,909 bp[2] End 89,099,418 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle sural nerve gonad Achilles tendon left ovary epithelium of colon right ovary adipose tissue stromal cell of endometrium subcutaneous adipose tissue Top expressed in Gonadal ridge ovary basal plate spermatocyte testicle ventricular zone superior frontal gyrus rhombencephalon mesencephalon central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled peptide receptor activity G protein-coupled receptor activity choriogonadotropin hormone binding signal transducer activity protein-hormone receptor activity choriogonadotropin hormone receptor activity follicle-stimulating hormone receptor activity luteinizing hormone receptor activity Cellular component integral component of membrane endosome membrane integral component of plasma membrane plasma membrane Biological process G protein-coupled receptor signaling pathway male gonad development male genitalia development cognition G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger activation of adenylate cyclase activity positive regulation of inositol trisphosphate biosynthetic process hormone-mediated signaling pathway cellular response to gonadotropin stimulus signal transduction primary ovarian follicle growth phospholipase C-activating G protein-coupled receptor signaling pathway follicle-stimulating hormone signaling pathway regulation of osteoclast differentiation luteinizing hormone signaling pathway positive regulation of adenylate cyclase activity cellular response to luteinizing hormone stimulus adenylate cyclase-activating G protein-coupled receptor signaling pathway ovulation cycle process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3973 16867 Ensembl ENSG00000138039 ENSMUSG00000024107 UniProt P22888 P30730 RefSeq (mRNA) NM_000233 NM_013582 NM_001364898 RefSeq (protein) NP_000224 NP_038610 NP_001351827 Location (UCSC) Chr 2: 48.69 – 48.76 Mb Chr 17: 89.02 – 89.1 Mb PubMed search [3] [4]
Wikidata
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The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR), is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.