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The Lytle family was a prominent American family that played significant roles in the settlement and development of Kentucky and Ohio from the late 18th to the mid-19th centuries. The family's prominence began with Captain William Lytle (1728–1797), who led settlers to Kentucky in 1780. His son, William Lytle II (1770–1831), became the first landed millionaire in the West and founded Cincinnati College and Cincinnati Law College. The family produced several notable figures, including William Haines Lytle (1826–1863), a lawyer, poet, and Brigadier General who died in the American Civil War. Lytles served in various conflicts, including the French and Indian War, the American Revolutionary War, the Mexican–American War, and the Civil War. The family's influence extended to politics, with members such as Robert Todd Lytle serving in the United States Congress. Their legacy is commemorated in Cincinnati's Lytle Park Historic District, which includes the site of the former Lytle mansion, donated to the city in 1903.