| M7GpppX diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.59 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) m7G5'ppp5'N(3'ppp5'N)n + H2O 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
- (2) 7-methylguanosine 5'-diphosphate + H2O 7-methylguanosine 5'-phosphate + phosphate
Decapping is a process in the control of eukaryotic mRNA degradation.
- ^ Malys N, McCarthy JE (October 2006). "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies". Journal of Molecular Biology. 363 (2): 370–82. doi:10.1016/j.jmb.2006.08.015. PMID 16963086.
- ^ Liu SW, Rajagopal V, Patel SS, Kiledjian M (June 2008). "Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme". The Journal of Biological Chemistry. 283 (24): 16427–36. doi:10.1074/jbc.M800341200. PMC 2423256. PMID 18441014.
- ^ Liu H, Rodgers ND, Jiao X, Kiledjian M (September 2002). "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". The EMBO Journal. 21 (17): 4699–708. doi:10.1093/emboj/cdf448. PMC 126188. PMID 12198172.
- ^ van Dijk E, Le Hir H, Séraphin B (October 2003). "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12081–6. Bibcode:2003PNAS..10012081V. doi:10.1073/pnas.1635192100. PMC 218716. PMID 14523240.
- ^ Chen N, Walsh MA, Liu Y, Parker R, Song H (April 2005). "Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping". Journal of Molecular Biology. 347 (4): 707–18. doi:10.1016/j.jmb.2005.01.062. PMID 15769464.